报告题目：DNA酶促氧化在生长发育与疾病发生中的作用

报告时间：2023年3月29日（周三）下午14:00

报告地点：武汉大学生命科学学院二楼报告厅

报 告 人：徐国良 中国科学院院士

主讲人简介：

徐国良，中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）研究员，复旦大学生物医学研究院教授兼执行院长。1985年获浙江大学生物学系学士学位、1988年获中国科学院遗传所硕士学位，1993年获德国马普分子遗传学研究所博士学位。先后在德国马普分子遗传学研究所、美国哥伦比亚大学遗传发育系和医学系做博士后研究。2001至2006任中国科学院与德国马普学会国际合作青年科学家小组组长，并获得“国家杰出青年科学基金”，2015年当选中国科学院院士。

徐国良院士长期致力于DNA的表观遗传修饰研究，在“DNA甲基化与去甲基化的分子机制”以及“重编程过程中的表观遗传调控机制”研究领域取得一系列国际前沿和领先成果，两次入选“中国科学十大进展”（2011年、2016年）。2012年获得第五届谈家桢生命科学创新奖，2014年获得陈嘉庚生命科学奖，2017年获得何梁何利科学与技术进步奖。近年来主要探究表观修饰及修饰酶在生长发育与肿瘤发生发展过程中的作用机制。

Brief Introduction of Professor Guoliang Xu

Guoliang Xu, research professor at the Center for Excellence in Molecular Cell Science, CAS, (Shanghai Institute of Biochemistry and Cell Biology), and professor and executive dean at the Biomedical Research Institute of Fudan University. He received his bachelor's degree from the Department of Biology at Zhejiang University in 1985, his master's degree from the Institute of Genetics, Chinese Academy of Sciences in 1988, and his PhD from the Max Planck Institute for Molecular Genetics in Germany in 1993. He did his postdoctoral research at the Max Planck Institute for Molecular Genetics in Germany, the Department of Genetics and Development at Columbia University in the United States, and the Department of Medicine at Columbia University. He served as the leader of the International Young Scientist Group of the Chinese Academy of Sciences and the Max Planck Society from 2001 to 2006, and was awarded the "The National Science Fund for Distinguished Young Scholars". He was elected as a member of the Chinese Academy of Sciences in 2015.

Academician Guoliang Xu has long been committed to the study of epigenetic modification of DNA. He has made a series of internationally leading achievements in the fields of "molecular mechanisms of DNA methylation and demethylation" and "epigenetic regulation mechanisms in reprogramming processes". His works have been twice selected as the "Top Ten Advances in Chinese Science" (2011 and 2016). He won the fifth C.C.Tan Life Science Innovation Award in 2012, the Tan Kah Kee Award of Life Sciences in 2014, and the Ho Leung Ho Lee Science and Technology Progress Award in 2017. His main interest recent years lies in the mechanism of epigenetic modification and modification enzymes in the process of growth and tumor development.